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What Makes Armodafinil Effective in Keeping Us Awake?

What Makes Armodafinil Effective in Keeping Us Awake?

Armodafinil is a drug that is an enantiopure compound of the drug Modafinil. The Armodafinil drug was the first available under the brand name Nuvigil and it is enantiomer of the drug present in the known brand Provigil.

Some people assume that Armodafinil can be used as a substitute for Modafinil. But it is not an entirely correct observation. It is true that just like Modafinil, Armodafinil too is a common prescription for the treatment of excessive sleep disorders. The known excessive sleep disorders such as Narcolepsy, daytime sleepiness are associated with Obstructive Sleep Apnea and Shift Work Sleep Disorder can be treated and managed with the help of the Armodafinil drug.

What Makes Armodafinil Effective In Keeping Excessive Sleepiness Away?

Being the only enantiopure compound of Modafinil, Armodafinil shares all its properties. We know that Modafinil is a eugeroic substance, implying that it belongs to a group of drugs that induce wakefulness and alertness.

This makes the Armodafinil drug a eugeroic substance as well, indicating that it is capable of making a person awake and alert.

Now let us dive into the working mechanism of the Armodafinil drug that allows its user to feel active and awake.

Even though Armodafinil has been approved by the U.S. Food and Drug Administration in 2007, there has been no exact agreement between the studies conducted to study its working mechanism.

It is since then been widely prescribed by doctors worldwide for dealing with conditions that cause excessive daytime sleepiness.

We have some information that can help us understand the working mechanism of Armodafinil.

Armodafinil works in a manner similar to the drugs which are dopamine reuptake inhibitors but it does not have strong effects associated with such drugs.

When the Armodafinil is in its active stage in a person’s body, the drug releases histamine and orexin neuropeptides, and these together with the release of dopamine cause a state of alertness and keep a person awake.

The same working mechanism is involved in the working of the drug Modafinil. However, it has been established that the effects induced by Armodafinil are stronger than that of Modafinil.

The Dopamine released in the brain due to the working mechanism of Armodafinil is responsible for controlling the motivation and reinforcement and the prospect of reward. This makes the brain more active as it is motivated and in search of an activity that can satisfy the brains need to be rewarded.

Histamine is released from the tuberomammillary nucleus due to the action of this drug. Histamine regulates physiological functions in the body and is also a central neurotransmitter.

The orexin neuropeptides released from the lateral hypothalamus can have a positive impact on wakefulness. People who suffer from Type 1 narcolepsy often have a lack of orexin (hypocretin) neuropeptides. This can be a contributing factor to the fact that the drug Armodafinil, as well as its main drug Modafinil both, are effective in treating narcolepsy.

These are some suggestions made after the conduction of various studies on the drugs Modafinil and Armodafinil. But even now many experts have not yet come to the conclusion regarding the exact working mechanism of the drug in keeping the person awake and alert.

Why is Armodafinil among the most recommended drug for the treatment of disorders related to Excessive Daytime Sleepiness?

Some people have used Modafinil in the past but have not experienced adequate relief from daytime sleepiness and the symptoms associated with it.

Armodafinil is recommended by doctors to such people as the plasma concentrations of this drug are higher than that of Modafinil.

The terminal half-life of Armodafinil is considered to be higher than that of Modafinil but the difference between them is not very big. The terminal half-life also differs based on the brand of the medication.

For instance, we have three brands of Armodafinil as Nuvigil and Artvigil. There are reports that indicate that users of Nuvigil and Waklert found no significant difference between them. But Artvigil 150 has been reported to have a quicker terminal half-life than a dose of Waklert 150.

Armodafinil is thus preferred by people who have found Modafinil to be ineffective in improving their symptoms.

Some people have daytime sleepiness symptoms that are so severe that doctors recommend the Armodafinil pills to them for the treatment of their symptoms.

Apart from using Armodafinil for the treatment of excessive sleep disorders such as Shift Work Sleep disorders, Obstructive Sleep Apnea, and Narcolepsy, doctors also prescribe it for various off-label uses.

Doctors may recommend the use of Armodafinil for the treatment of depression, anxiety, Attention Deficit Hyperactivity Disorder (ADHD), and Attention Deficit Disorder (ADD).

Armodafinil can also be prescribed for the treatment of chronic fatigue syndrome as well but some doctors are divided about the effects of this drug and the safety of its use.

Apart from medical uses, Armodafinil is quite popular in the bio hacking space. Many bio hackers make use of the Armodafinil drug for boosting their productivity, improving their concentration span.

Many students also make use of Armodafinil to get ahead in academic life as the dopamine released with its use also boosts problem-solving and generates a feeling or desire that helps them complete tasks faster. It also reduces the tendency to get distracted from the tasks at hand which allows them to work on with precision and accuracy. People who use it for controlling daytime sleepiness also report improvement in their cognitive functions.

People suffering from Shift work sleeping disorders have reported that they experience a state of increased alertness after taking a pill of Armodafinil. This prevents accidents and miscalculations that often occur if people are drowsy while at work. The productivity goes up as the people can finish their tasks at far better speed and with higher accuracy. Also, the working mechanism of Armodafinil which releases dopamine makes them desire more tasks. This is because the release of dopamine in the brain activates the will to complete tasks and motivates their brain and triggers their body to take actions.

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